Genetic Polymorphism of Angiotensin II Type 1 Receptors and Their Effect on the Clinical Outcome of Captopril Treatment in Arab Iraqi Patients with Acute Coronary Syndrome (Mid Euphrates)     

Fadhaa A. Ghafil  Bassim I. Mohammad  Hussain S. Al-Janabi  Najah R. Hadi  Hayder A. Al-Aubaidy 《Indian journal of clinical biochemistry : IJCB》2021,36(1):81

Genetic variation in the angiotensin II type 1 receptor (AT1R) has an important effect on the outcome of acute coronary syndrome (ACS) initiated treatment with captopril. This study aims to investigate the impact of genetic polymorphism of AT1R (rs5186 and rs275651) on the ACS outcome in Iraqi patients treated with captopril. A total of 250 Iraqi individuals with ACS were included in this case—control study and they were divided into two study groups; Study group 1 included 125 participants who were prescribed captopril, 25 mg twice daily and study group 2 included 125 participants who received no captopril as part of their ACS treatment (control study). The AT1R gene (rs5186) CC genotype was found to be associated with ST-elevation myocardial infarction (STEMI) (Odd’s ratio (O.R) = 1.2, P = 0.7), while AC was associated with Non-ST-elevation myocardial infarction (NSTEMI) and unstable angina (UA) (O.R = 1.2, P = 0.8). AC genotype is more prone to have Percutaneous coronary intervention (PCI) after ACS attack (O.R = 1.2, P = 0.6). CC genotype had a risk to get less improvement (O.R = 1.6, P = 0.5), so might require higher doses of captopril during acute coronary insult. The AT1R gene (rs275651) AA genotype was associated with UA (O.R = 1.3, P = 0.9). AA and AT genotypes were more prone to have PCI after ACS attack (O.R = 3.9 P = 0.2, O.R = 3.5, P = 0.3 respectively) and thus requiring higher doses of captopril. We conclude that the AT1R rs5186, rs275651 genetic polymorphisms might partially affect the clinical outcome of ACS patients treated with captopril and might have captopril resistance which requires higher doses.  相似文献   

下一代图书馆系统平台的实践与思考     

邵波  张文竹 《图书情报工作》2019,63(1):98-104

[目的/意义]大数据与人工智能等技术为图书馆智慧服务带来机遇与挑战，图书馆新系统平台建设刻不容缓。旨在探讨下一代图书馆系统平台发展现状及对策，为建设一流高校智慧图书馆提供实践案例与参考依据。[方法/过程]梳理图书馆系统平台发展脉络，在盘点现有的国内外下一代图书馆系统平台的研究与实践的基础上，以南京大学为例，探索图书馆新系统平台的建设方案。[结果/结论]智慧图书馆将通过建设一体化电子资源管理平台并打造NLSP，提升图书馆资源管控和知识服务水平，构建开放共享的智慧图书馆服务体系。  相似文献   

图书馆科普教育现状与发展路径探究——基于25个省市88家科普教育基地调查     

徐基田 《图书情报工作》2020,64(9):35-45

[目的/意义] 图书馆肩负着实施科普教育的法定职责，拥有品种多样、内容丰富的科普文献与信息资源的图书馆，在开展科普教育方面具有得天独厚的优势。图书馆科普教育起步比较早，2005年，中国图书馆学会成立科普与阅读指导委员会；但在图书馆业界，科普教育只是零星的点缀式服务创新探索，尚未成为常态化服务项目。在依法治馆、创新发展的新时代，寻求图书馆科普教育发展路径具有较强理论和实践意义。[方法/过程] 通过互联网、微信等社交网络平台，对图书馆科普教育基地建设的状况进行调研，从基地等级、基地类型、基地数量、区域分布、有效期限以及认定依据等方面进行深入分析，并对图书馆实施科普教育提出发展路径以供选择。[结果/结论] 图书馆科普教育应坚持基地建设与科普服务相结合、阅读推广与全民科普相融合、科普与游学并举等策略，走设施、资源、服务"三位一体"的持续稳健协调发展之路。  相似文献   

Data Visualization as Participatory Research: A Model for Digital Collections to Inspire User-Driven Research     

A. Miller 《Journal of Web Librarianship》2019,13(2):127-155

The emerging creative practices of digital collections are increasing in prominence thanks to the access to, and appeal of, data visualizations. Interactive data visualizations, such as a map, timeline, chart, graph, or artist’s rendering of data, enable users to pursue their own research interests within a collection and participate in new areas of research. Use of these data visualizations enhances the scope of the collection and enables a modern and diverse thematic collection to emerge. This article considers the question: Does the addition of data visualizations affect how users participate with a research collection? Impacts on collection development, application of user-centered design, and analysis of users’ exploratory strategies are discussed. Examples of data visualizations used in digital humanities projects and digital collections are presented as case studies.  相似文献   

上海市黄浦区社会体育组织培育现状及转型发展研究          下载免费PDF全文

战旗  王海银  刘忠亚  孟欢欢 《体育科研》2020,(1):69-74

采用文献资料法、访谈法等,了解到上海市黄浦区政府培育社会体育组织发展的现状以及存在的问题,提出针对性的发展路径。研究表明:经过阶段性的培育,目前上海市黄浦区社会体育组织结构较完整,规模初现,功能呈现多元化,制度建设日益完善,监督评估机制雏形初显;但培育过程中存在着党建嵌入不足,培育主体较为单一,培育体制机制不完善,培育制度保障体系不健全等问题。提出培育路径:创新党建嵌入方式,实行组织党建工作制度化;搭建组织服务平台,拓宽组织准入范围;分类、分阶段针对性的培育,健全培育体制机制;完善组织制度建设,提升组织服务能力。  相似文献   

新时代我国少数民族地区体育公共服务分层治理研究     

秦小平  胡庆山  鲁长芬  王健 《武汉体育学院学报》2019,53(8):5

采用文献资料法等研究方法对新时代我国少数民族地区体育公共服务分层治理进行研究，旨在为提高我国少数民族地区体育公共服务质量和建设体育强国提供建议。研究认为，少数民族地区体育公共服务分层治理是基于我国社会分层的现状以及各阶层体育需求和参与特征存在的差异而采取的差异性治理方式，分层治理有"因层制宜"的意蕴，有利于促进我国少数民族地区体育公共服务均等化和改变少数民族地区体育公共服务"供给不足"和"供非所需"的困境。现阶段我国少数民族地区体育公共服务分层治理的思路包括明确少数民族地区体育公共服务分层治理主体责任、完善少数民族地区体育公共服务分层治理资金保障机制、积极探索少数民族地区体育公共服务分层供给方式、构建少数民族地区体育公共服务分层治理协商机制、建立少数民族地区体育公共服务分层供给绩效评价体系。  相似文献   

可持续发展视角下全民健身服务体系的内涵解析     

梁法泽  聂瑞莲  侯玉灵 《体育科技文献通报》2020,(1):10-12

本文以可持续发展为视角,阐述了可持续发展视角下全民健身服务体系内涵。利用文献资料法、实地考察法及专家访谈法,对可持续发展视角下全民健身服务体系发展现状进行了简单分析。进一步探究了可持续发展视角下全民健身服务体系建设路径,以期为可持续发展视角下全民健身服务体系建设提供有效的借鉴。  相似文献   

协同搜索过程中用户交流内容与模式研究     

张璐  张鹏翼  刘畅 《图书情报知识》2020,(3):51-62

[目的/意义]旨在分析协同搜索用户在信息搜索任务过程中的交流内容与模式,从而理解协同搜索用户的关注重点与搜索过程。[研究设计/方法]基于书籍交互检索平台(CLEF-Social Book Search)设计实验,共招募18名被试完成两种搜索任务,通过录音记录对话并对其进行编码和分析,总结交流内容特征和模式。结合任务类型、认知类型组合、服务器记录的搜索交互行为日志以及问卷收集的搜索体验进行了探索分析。[结论/发现]从交流内容上看,协同搜索用户主要理解与评判书目信息、商讨搜索任务计划;比起认知类型不同的用户,相同认知类型的用户在操作交互方面交流更多,在评判决策方面交流较少。交流模式依据讨论内容比重可分为理解评判型、评判主导型、均衡交流型三种,评判主导型用户的任务完成满意度最高。[创新/价值]协同搜索用户的交流反映出搜索过程中需要与同伴商讨协同的焦点,也是需要系统提供协助的重点,给协同搜索系统设计提供一定参考。本研究针对协同搜索的交流内容设计的编码系统对相关的协同交流研究也有借鉴意义。  相似文献   

Beyond traditional collaborative search: Understanding the effect of awareness on multi-level collaborative information retrieval     

Nyi Nyi Htun  Martin Halvey  Lynne Baillie 《Information processing & management》2018,54(1):60-87

Although there has been a great deal of research into Collaborative Information Retrieval (CIR) and Collaborative Information Seeking (CIS), the majority has assumed that team members have the same level of unrestricted access to underlying information. However, observations from different domains (e.g. healthcare, business, etc.) have suggested that collaboration sometimes involves people with differing levels of access to underlying information. This type of scenario has been referred to as Multi-Level Collaborative Information Retrieval (MLCIR). To the best of our knowledge, no studies have been conducted to investigate the effect of awareness, an existing CIR/CIS concept, on MLCIR. To address this gap in current knowledge, we conducted two separate user studies using a total of 5 different collaborative search interfaces and 3 information access scenarios. A number of Information Retrieval (IR), CIS and CIR evaluation metrics, as well as questionnaires were used to compare the interfaces. Design interviews were also conducted after evaluations to obtain qualitative feedback from participants. Results suggested that query properties such as time spent on query, query popularity and query effectiveness could allow users to obtain information about team's search performance and implicitly suggest better queries without disclosing sensitive data. Besides, having access to a history of intersecting viewed, relevant and bookmarked documents could provide similar positive effect as query properties. Also, it was found that being able to easily identify different team members and their actions is important for users in MLCIR. Based on our findings, we provide important design recommendations to help develop new CIR and MLCIR interfaces.  相似文献   

高校图书馆的创新管理   总被引：4，自引：0，他引：4  

常晓群  丁菁梅 《大学图书情报学刊》2003,21(2):31-32,39

从网络时代图书馆客观环境和读者需求出发，阐述新时期图书馆的现代化建设，提出图书馆的创新管理内容，以及图书馆的管理新概念。  相似文献